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PGC-1α Is a Central Negative Regulator of Vascular Senescence

OBJECTIVE: Cellular senescence influences organismal aging and increases predisposition to age-related diseases, in particular cardiovascular disease, a leading cause of death and disability worldwide. PGC-1α is a master regulator of mitochondrial biogenesis and function, oxidative stress and insuli...

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Detalhes bibliográficos
Main Authors: Xiong, Shiqin, Salazar, Gloria, Patrushev, Nikolay, Ma, Minhui, Forouzandeh, Farshad, Hilenski, Lula, Alexander, R. Wayne
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3663327/
https://ncbi.nlm.nih.gov/pubmed/23430617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.112.301019
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