Early Endosomal Antigen 1 (EEA1) Is an Obligate Scaffold for Angiotensin II-induced, PKC-α-dependent Akt Activation in Endosomes

Akt/protein kinase B (PKB) activation/phosphorylation by angiotensin II (Ang II) is a critical signaling event in hypertrophy of vascular smooth muscle cells (VSMCs). Conventional wisdom asserts that Akt activation occurs mainly in plasma membrane domains. Recent evidence that Akt activation may tak...

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Detalhes bibliográficos
Main Authors: Nazarewicz, Rafal Robert, Salazar, Gloria, Patrushev, Nikolay, Martin, Alejandra San, Hilenski, Lula, Xiong, Shiqin, Alexander, R. Wayne
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3024784/
https://ncbi.nlm.nih.gov/pubmed/21097843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.141499
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