FoxO1 Mediates an Autofeedback Loop Regulating SIRT1 Expression

Forkhead transcription factor FoxO1 and the NAD(+)-dependent histone deacetylase SIRT1 are evolutionarily conserved regulators of the development of aging, oxidative stress resistance, insulin resistance, and metabolism in species ranging from invertebrates to mammals. SIRT1 deacetylates FoxO1 and e...

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Bibliographic Details
Main Authors: Xiong, Shiqin, Salazar, Gloria, Patrushev, Nikolay, Alexander, R. Wayne
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Gene Regulation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3037641/
https://ncbi.nlm.nih.gov/pubmed/21149440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.163667
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