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FoxO1 Mediates an Autofeedback Loop Regulating SIRT1 Expression

Forkhead transcription factor FoxO1 and the NAD(+)-dependent histone deacetylase SIRT1 are evolutionarily conserved regulators of the development of aging, oxidative stress resistance, insulin resistance, and metabolism in species ranging from invertebrates to mammals. SIRT1 deacetylates FoxO1 and e...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Xiong, Shiqin, Salazar, Gloria, Patrushev, Nikolay, Alexander, R. Wayne
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3037641/
https://ncbi.nlm.nih.gov/pubmed/21149440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.163667
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