Ryanodine receptor inhibition potentiates the activity of Na channel blockers against spontaneous calcium elevations and delayed afterdepolarizations in Langendorff-perfused rabbit ventricles

BACKGROUND: Na channel blockers are effective in suppressing delayed afterdepolarizations (DADs) in isolated Purkinje fibers. However, in isolated mouse ventricular myocytes lacking calsequestrin, only those Na channel blockers that also inhibit type 2 ryanodine receptor channels were effective agai...

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Hoofdauteurs: Lee, Young Soo, Maruyama, Mitsunori, Chang, Po Cheng, Park, Hyung Wook, Rhee, Kyoung-Suk, Hsieh, Yu-Cheng, Hsueh, Chia-Hsiang, Shen, Changyu, Lin, Shien-Fong, Hwang, Hyun Seok, Yin, Huiyong, Knollmann, Björn C., Chen, Peng-Sheng
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2012
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3572724/
https://ncbi.nlm.nih.gov/pubmed/22387372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.hrthm.2012.02.031
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