Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a potentially lethal inherited arrhythmia syndrome in which drug therapy is often ineffective. We discovered that flecainide prevents arrhythmias in a mouse model of CPVT by inhibiting cardiac ryanodine receptor–mediated Ca(2+) release...

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Hlavní autoři: Watanabe, Hiroshi, Chopra, Nagesh, Laver, Derek, Hwang, Hyun Seok, Davies, Sean S, Roach, Daniel E, Duff, Henry J, Roden, Dan M, Wilde, Arthur A M, Knollmann, Björn C
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2904954/
https://ncbi.nlm.nih.gov/pubmed/19330009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.1942
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