Focal Energy Deprivation Underlies Arrhythmia Susceptibility in Mice with Calcium-Sensitized Myofilaments

RATIONALE: The Ca(2+) sensitivity of the myofilaments is increased in hypertrophic cardiomyopathy (HCM) and other heart diseases and may contribute to a higher risk for sudden cardiac death (SCD). Ca(2+) sensitization increases susceptibility to reentrant ventricular tachycardia in animal models, bu...

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Bibliographic Details
Main Authors: Huke, Sabine, Venkataraman, Raghav, Faggioni, Michela, Bennuri, Sirish, Hwang, Hyun S., Baudenbacher, Franz, Knollmann, Björn C.
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3850761/
https://ncbi.nlm.nih.gov/pubmed/23532597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.113.301055
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