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Predicting Cardiomyopathic Phenotypes by Altering Ca(2+) Affinity of Cardiac Troponin C

Cardiac diseases associated with mutations in troponin subunits include hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM), and restrictive cardiomyopathy (RCM). Altered calcium handling in these diseases is evidenced by changes in the Ca(2+) sensitivity of contraction. Mutations in the...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Parvatiyar, Michelle S., Pinto, Jose Renato, Liang, Jingsheng, Potter, James D.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2010
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2934646/
https://ncbi.nlm.nih.gov/pubmed/20566645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.112326
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