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Predicting Cardiomyopathic Phenotypes by Altering Ca(2+) Affinity of Cardiac Troponin C

Cardiac diseases associated with mutations in troponin subunits include hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM), and restrictive cardiomyopathy (RCM). Altered calcium handling in these diseases is evidenced by changes in the Ca(2+) sensitivity of contraction. Mutations in the...

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Bibliografiske detaljer
Main Authors: Parvatiyar, Michelle S., Pinto, Jose Renato, Liang, Jingsheng, Potter, James D.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2934646/
https://ncbi.nlm.nih.gov/pubmed/20566645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.112326
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