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Predicting Cardiomyopathic Phenotypes by Altering Ca(2+) Affinity of Cardiac Troponin C
Cardiac diseases associated with mutations in troponin subunits include hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM), and restrictive cardiomyopathy (RCM). Altered calcium handling in these diseases is evidenced by changes in the Ca(2+) sensitivity of contraction. Mutations in the...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Biochemistry and Molecular Biology
2010
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2934646/ https://ncbi.nlm.nih.gov/pubmed/20566645 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.112326 |
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