Analysis of the Molecular Pathogenesis of Cardiomyopathy-Causing cTnT Mutants I79N, ΔE96, and ΔK210

Por Bai, Fan, Caster, Hannah M., Pinto, Jose R., Kawai, Masataka
Publicado em 2013

A Dilated Cardiomyopathy Troponin C Mutation Lowers Contractile Force by Reducing Strong Myosin-Actin Binding

Por Dweck, David, Reynaldo, Daniel P., Pinto, Jose R., Potter, James D.
Publicado em 2010

Fluorescent Protein-Based Ca(2+) Sensor Reveals Global, Divalent Cation-Dependent Conformational Changes in Cardiac Troponin C

Por Badr, Myriam A., Pinto, Jose R., Davidson, Michael W., Chase, P. Bryant
Publicado no PLoS One (2016)

Structural and protein interaction effects of hypertrophic and dilated cardiomyopathic mutations in alpha-tropomyosin

Por Chang, Audrey N., Greenfield, Norma J., Singh, Abhishek, Potter, James D., Pinto, Jose R.
Publicado no Front Physiol (2014)

Enhanced troponin I binding explains the functional changes produced by the hypertrophic cardiomyopathy mutation A8V of cardiac troponin C

Por Zot, Henry G., Hasbun, Javier E., Michell, Clara A., Landim-Vieira, Maicon, Pinto, Jose R.
Publicado no Arch Biochem Biophys (2016)

Myosin Rod Hypophosphorylation and CB Kinetics in Papillary Muscles from a TnC-A8V KI Mouse Model

Por Kawai, Masataka, Johnston, Jamie R., Karam, Tarek, Wang, Li, Singh, Rakesh K., Pinto, Jose R.
Publicado no Biophys J (2017)

Absence of Myocardial Thyroid Hormone Inactivating Deiodinase Results in Restrictive Cardiomyopathy in Mice

Por Ueta, Cintia B., Oskouei, Behzad N., Olivares, Emerson L., Pinto, Jose R., Correa, Mayrin M., Simovic, Gordana, Simonides, Warner S., Hare, Joshua M., Bianco, Antonio C.
Publicado em 2012

Molecular and Functional Characterization of Novel Hypertrophic Cardiomyopathy Susceptibility Mutations in TNNC1- Encoded Troponin C

Por Landstrom, Andrew P., Parvatiyar, Michelle S., Pinto, Jose R., Marquardt, Michelle L., Bos, J. Martijn, Tester, David J., Ommen, Steve R., Potter, James D., Ackerman, Michael J.
Publicado em 2008

Genotype‐specific pathogenic effects in human dilated cardiomyopathy

Por Bollen, Ilse A. E., Schuldt, Maike, Harakalova, Magdalena, Vink, Aryan, Asselbergs, Folkert W., Pinto, Jose R., Krüger, Martina, Kuster, Diederik W. D., van der Velden, Jolanda
Publicado no J Physiol (2017)

Constitutive Phosphorylation of Cardiac Myosin Regulatory Light Chain in Vivo

Por Chang, Audrey N., Battiprolu, Pavan K., Cowley, Patrick M., Chen, Guohua, Gerard, Robert D., Pinto, Jose R., Hill, Joseph A., Baker, Anthony J., Kamm, Kristine E., Stull, James T.
Publicado no J Biol Chem (2015)

Hypertrophic Cardiomyopathy Cardiac Troponin C Mutations Differentially Affect Slow Skeletal and Cardiac Muscle Regulation

Por Veltri, Tiago, Landim-Vieira, Maicon, Parvatiyar, Michelle S., Gonzalez-Martinez, David, Dieseldorff Jones, Karissa M., Michell, Clara A., Dweck, David, Landstrom, Andrew P., Chase, P. Bryant, Pinto, Jose R.
Publicado no Front Physiol (2017)

Amide hydrogens reveal a temperature-dependent structural transition that enhances site-II Ca(2+)-binding affinity in a C-domain mutant of cardiac troponin C

Por Veltri, Tiago, de Oliveira, Guilherme A. P., Bienkiewicz, Ewa A., Palhano, Fernando L., Marques, Mayra de A., Moraes, Adolfo H., Silva, Jerson L., Sorenson, Martha M., Pinto, Jose R.
Publicado no Sci Rep (2017)

Pathogenesis of depression- and anxiety-like behavior in an animal model of hypertrophic cardiomyopathy

Por Dossat, Amanda M., Sanchez-Gonzalez, Marcos A., Koutnik, Andrew P., Leitner, Stefano, Ruiz, Edda L., Griffin, Brittany, Rosenberg, Jens T., Grant, Samuel C., Fincham, Francis D., Pinto, Jose R., Kabbaj, Mohamed
Publicado no FASEB J (2017)

Collagen XIV is important for growth and structural integrity of the myocardium

Por Tao, Ge, Levay, Agata K., Peacock, Jacqueline D., Huk, Danielle J., Both, Sarah N., Purcell, Nicole H., Pinto, Jose R., Galantowicz, Maarten L., Koch, Manuel, Lucchesi, Pamela A., Birk, David E., Lincoln, Joy
Publicado em 2012

Long Term Ablation of Protein Kinase A (PKA)-mediated Cardiac Troponin I Phosphorylation Leads to Excitation-Contraction Uncoupling and Diastolic Dysfunction in a Knock-in Mouse Mo...

Por Dweck, David, Sanchez-Gonzalez, Marcos A., Chang, Audrey N., Dulce, Raul A., Badger, Crystal-Dawn, Koutnik, Andrew P., Ruiz, Edda L., Griffin, Brittany, Liang, Jingsheng, Kabbaj, Mohamed, Fincham, Frank D., Hare, Joshua M., Overton, J. Michael, Pinto, Jose R.
Publicado em 2014

In vivo Analysis of Troponin C Knock-in (A8V) Mice: Evidence that TNNC1 Is a Hypertrophic Cardiomyopathy Susceptibility Gene

Por Martins, Adriano S., Parvatiyar, Michelle S., Feng, Han-Zhong, Bos, J. Martijn, Gonzalez-Martinez, David, Vukmirovic, Milica, Turna, Rajdeep S., Sanchez-Gonzalez, Marcos A., Badger, Crystal-Dawn, Zorio, Diego A. R., Singh, Rakesh K., Wang, Yingcai, Jin, J.-P., Ackerman, Michael J., Pinto, Jose R.
Publicado no Circ Cardiovasc Genet (2015)