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Structural and protein interaction effects of hypertrophic and dilated cardiomyopathic mutations in alpha-tropomyosin

The potential alterations to structure and associations with thin filament proteins caused by the dilated cardiomyopathy (DCM) associated tropomyosin (Tm) mutants E40K and E54K, and the hypertrophic cardiomyopathy (HCM) associated Tm mutants E62Q and L185R, were investigated. In order to ascertain w...

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Detalhes bibliográficos
Publicado no:Front Physiol
Main Authors: Chang, Audrey N., Greenfield, Norma J., Singh, Abhishek, Potter, James D., Pinto, Jose R.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4251307/
https://ncbi.nlm.nih.gov/pubmed/25520664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2014.00460
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