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Structural and protein interaction effects of hypertrophic and dilated cardiomyopathic mutations in alpha-tropomyosin

The potential alterations to structure and associations with thin filament proteins caused by the dilated cardiomyopathy (DCM) associated tropomyosin (Tm) mutants E40K and E54K, and the hypertrophic cardiomyopathy (HCM) associated Tm mutants E62Q and L185R, were investigated. In order to ascertain w...

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發表在:Front Physiol
Main Authors: Chang, Audrey N., Greenfield, Norma J., Singh, Abhishek, Potter, James D., Pinto, Jose R.
格式: Artigo
語言:Inglês
出版: Frontiers Media S.A. 2014
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4251307/
https://ncbi.nlm.nih.gov/pubmed/25520664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2014.00460
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