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Noncanonical EF-hand motif strategically delays Ca(2+) buffering to enhance cardiac performance

EF-hand proteins are ubiquitous in cell signaling. Parvalbumin (Parv), the archetypal EF-hand protein, is a high-affinity Ca(2+) buffer in many biological systems. Given the centrality of Ca(2+) signaling in health and disease, EF-hand motifs designed to have new biological activities may have wides...

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Detalhes bibliográficos
Main Authors: Wang, Wang, Barnabei, Matthew S, Asp, Michelle L, Heinis, Frazer I, Arden, Erik, Davis, Jennifer, Braunlin, Elizabeth, Li, Qi, Davis, Jonathan P, Potter, James D, Metzger, Joseph M
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3727912/
https://ncbi.nlm.nih.gov/pubmed/23396207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3079
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