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Noncanonical EF-hand motif strategically delays Ca(2+) buffering to enhance cardiac performance
EF-hand proteins are ubiquitous in cell signaling. Parvalbumin (Parv), the archetypal EF-hand protein, is a high-affinity Ca(2+) buffer in many biological systems. Given the centrality of Ca(2+) signaling in health and disease, EF-hand motifs designed to have new biological activities may have wides...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2013
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3727912/ https://ncbi.nlm.nih.gov/pubmed/23396207 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3079 |
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