Effects of Modified Parvalbumin EF-Hand Motifs on Cardiac Myocyte Contractile Function

Cardiac gene delivery of parvalbumin (Parv), an EF-hand Ca(2+) buffer, has been studied as a therapeutic strategy for diastolic heart failure, in which slow Ca(2+) reuptake is an important contributor. A limitation of wild-type (WT) Parv is the significant trade-off between faster relaxation and blu...

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Detalles Bibliográficos
Publicado en:Biophys J
Autores principales: Asp, Michelle L., Sjaastad, Frances V., Siddiqui, Jalal K., Davis, Jonathan P., Metzger, Joseph M.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Biophysical Society 2016
Materias:
Cell Biophysics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4940608/
https://ncbi.nlm.nih.gov/pubmed/27166817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2016.03.037
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