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Effects of Modified Parvalbumin EF-Hand Motifs on Cardiac Myocyte Contractile Function
Cardiac gene delivery of parvalbumin (Parv), an EF-hand Ca(2+) buffer, has been studied as a therapeutic strategy for diastolic heart failure, in which slow Ca(2+) reuptake is an important contributor. A limitation of wild-type (WT) Parv is the significant trade-off between faster relaxation and blu...
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| Publié dans: | Biophys J |
|---|---|
| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
The Biophysical Society
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4940608/ https://ncbi.nlm.nih.gov/pubmed/27166817 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2016.03.037 |
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