RNA interference

Por Paddison, Patrick J., Vogt, Peter K.
Publicado em 2008

Stable suppression of gene expression by RNAi in mammalian cells

Por Paddison, Patrick J., Caudy, Amy A., Hannon, Gregory J.
Publicado em 2002

Wnt and TGF-β signaling are required for the induction of an in vitro model of primitive streak formation using embryonic stem cells

Por Gadue, Paul, Huber, Tara L., Paddison, Patrick J., Keller, Gordon M.
Publicado em 2006

G9a/GLP-dependent H3K9me2 patterning alters chromatin structure at CpG islands in hematopoietic progenitors

Por Schones, Dustin E, Chen, Xiaoji, Trac, Candi, Setten, Ryan, Paddison, Patrick J
Publicado em 2014

Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells

Por Paddison, Patrick J., Caudy, Amy A., Bernstein, Emily, Hannon, Gregory J., Conklin, Douglas S.
Publicado em 2002

Exit from Pluripotency Is Gated by Intracellular Redistribution of the bHLH Transcription Factor Tfe3

Por Betschinger, Joerg, Nichols, Jennifer, Dietmann, Sabine, Corrin, Philip D., Paddison, Patrick J., Smith, Austin
Publicado em 2013

Molecular Pathways: Regulation and Targeting of Kinetochore–Microtubule Attachment in Cancer

Por Herman, Jacob A., Toledo, Chad M., Olson, James M., DeLuca, Jennifer G., Paddison, Patrick J.
Publicado no Clin Cancer Res (2014)

Causal mechanistic regulatory network for glioblastoma deciphered using systems genetics network analysis

Por Plaisier, Christopher L., O’Brien, Sofie, Bernard, Brady, Reynolds, Sheila, Simon, Zac, Toledo, Chad M., Ding, Yu, Reiss, David J., Paddison, Patrick J., Baliga, Nitin S.
Publicado no Cell Syst (2016)

G9a/GLP-dependent histone H3K9me2 patterning during human hematopoietic stem cell lineage commitment

Por Chen, Xiaoji, Skutt-Kakaria, Kyobi, Davison, Jerry, Ou, Yang-Li, Choi, Edward, Malik, Punam, Loeb, Keith, Wood, Brent, Georges, George, Torok-Storb, Beverly, Paddison, Patrick J.
Publicado em 2012

Ion channel expression patterns in glioblastoma stem cells with functional and therapeutic implications for malignancy

Por Pollak, Julia, Rai, Karan G., Funk, Cory C., Arora, Sonali, Lee, Eunjee, Zhu, Jun, Price, Nathan D., Paddison, Patrick J., Ramirez, Jan-Marino, Rostomily, Robert C.
Publicado no PLoS One (2017)

ZNF131 suppresses centrosome fragmentation in glioblastoma stem-like cells through regulation of HAUS5

Por Ding, Yu, Herman, Jacob A., Toledo, Chad M., Lang, Jackie M., Corrin, Philip, Girard, Emily J., Basom, Ryan, Delrow, Jeffrey J., Olson, James M., Paddison, Patrick J.
Publicado no Oncotarget (2017)

BuGZ is required for Bub3 stability, Bub1 kinetochore function, and chromosome alignment

Por Toledo, Chad M., Herman, Jacob A., Olsen, Jonathan B., Ding, Yu, Corrin, Philip, Girard, Emily J., Olson, James M., Emili, Andrew, DeLuca, Jennifer G., Paddison, Patrick J.
Publicado em 2014

Pathogenesis of ELANE-mutant severe neutropenia revealed by induced pluripotent stem cells

Por Nayak, Ramesh C., Trump, Lisa R., Aronow, Bruce J., Myers, Kasiani, Mehta, Parinda, Kalfa, Theodosia, Wellendorf, Ashley M., Valencia, C. Alexander, Paddison, Patrick J., Horwitz, Marshall S., Grimes, H. Leighton, Lutzko, Carolyn, Cancelas, Jose A.
Publicado no J Clin Invest (2015)

Screen for reactivation of MeCP2 on the inactive X chromosome identifies the BMP/TGF-β superfamily as a regulator of XIST expression

Por Sripathy, Smitha, Leko, Vid, Adrianse, Robin L., Loe, Taylor, Foss, Eric J., Dalrymple, Emily, Lao, Uyen, Gatbonton-Schwager, Tonibelle, Carter, Kelly T., Payer, Bernhard, Paddison, Patrick J., Grady, William M., Lee, Jeannie T., Bartolomei, Marisa S., Bedalov, Antonio
Publicado no Proc Natl Acad Sci U S A (2017)

GENE-30. TRANSCRIPTION ELONGATION FACTORS REPRESENT IN VIVO CANCER DEPENDENCIES IN GLIOBLASTOMA

Por Miller, Tyler E, Liau, Brian, Wallace, Lisa C, Morton, Andrew, Xie, Qi, Dixit, Deobrat, Factor, Daniel, Kim, Leo, Morrow, James, Wu, Qiulian, Mack, Stephen, Hubert, Christopher, Paddison, Patrick J, Horbinski, Craig, Bernstein, Bradley, Tesar, Paul, Rich, Jeremy
Publicado no Neuro Oncol (2017)

Genome-wide RNAi screen identifies miR-19 targets in Notch-induced acute T-cell leukaemia (T-ALL)

Por Mavrakis, Konstantinos J., Wolfe, Andrew L., Oricchio, Elisa, Palomero, Teresa, de Keersmaecker, Kim, McJunkin, Katherine, Zuber, Johannes, James, Taneisha, Chang, Kenneth, Khan, Aly A., Leslie, Christina S., Parker, Joel S., Paddison, Patrick J., Tam, Wayne, Ferrando, Adolfo, Wendel, Hans-Guido
Publicado em 2010

In vivo RNAi screen identifies NLK as a negative regulator of mesenchymal activity in glioblastoma

Por Sa, Jason K., Yoon, Yeup, Kim, Misuk, Kim, Yeonghwan, Cho, Hee Jin, Lee, Jin-Ku, Kim, Gi-Soo, Han, Suji, Kim, Woon Jin, Shin, Yong Jae, Joo, Kyeung Min, Paddison, Patrick J., Ishitani, Tohru, Lee, Jeongwu, Nam, Do-Hyun
Publicado no Oncotarget (2015)

Genome-wide RNAi screens in human brain tumor isolates reveal a novel viability requirement for PHF5A

Por Hubert, Christopher G., Bradley, Robert K., Ding, Yu, Toledo, Chad M., Herman, Jacob, Skutt-Kakaria, Kyobi, Girard, Emily J., Davison, Jerry, Berndt, Jason, Corrin, Philip, Hardcastle, Justin, Basom, Ryan, Delrow, Jeffery J., Webb, Thomas, Pollard, Steven M., Lee, Jeongwu, Olson, James M., Paddison, Patrick J.
Publicado em 2013

Cancer-specific requirement for BUB1B/BubR1 in human brain tumor isolates and genetically transformed cells

Por Ding, Yu, Hubert, Christopher G., Herman, Jacob, Corrin, Philip, Toledo, Chad M., Skutt-Kakaria, Kyobi, Vazquez, Julio, Basom, Ryan, Zhang, Bin, Risler, Jennifer K., Pollard, Steven M., Nam, Do-Hyun, Delrow, Jeffery J., Zhu, Jun, Lee, Jeongwu, DeLuca, Jennifer, Olson, James M., Paddison, Patrick J.
Publicado em 2012

A High-Content Small Molecule Screen Identifies Sensitivity of Glioblastoma Stem Cells to Inhibition of Polo-Like Kinase 1

Por Danovi, Davide, Folarin, Amos, Gogolok, Sabine, Ender, Christine, Elbatsh, Ahmed M. O., Engström, Pär G., Stricker, Stefan H., Gagrica, Sladjana, Georgian, Ana, Yu, Ding, U, Kin Pong, Harvey, Kevin J., Ferretti, Patrizia, Paddison, Patrick J., Preston, Jane E., Abbott, N. Joan, Bertone, Paul, Smith, Austin, Pollard, Steven M.
Publicado em 2013