Genome-wide RNAi screens in human brain tumor isolates reveal a novel viability requirement for PHF5A

To identify key regulators of human brain tumor maintenance and initiation, we performed multiple genome-wide RNAi screens in patient-derived glioblastoma multiforme (GBM) stem cells (GSCs). These screens identified the plant homeodomain (PHD)-finger domain protein PHF5A as differentially required f...

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Detalhes bibliográficos
Main Authors: Hubert, Christopher G., Bradley, Robert K., Ding, Yu, Toledo, Chad M., Herman, Jacob, Skutt-Kakaria, Kyobi, Girard, Emily J., Davison, Jerry, Berndt, Jason, Corrin, Philip, Hardcastle, Justin, Basom, Ryan, Delrow, Jeffery J., Webb, Thomas, Pollard, Steven M., Lee, Jeongwu, Olson, James M., Paddison, Patrick J.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2013
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3656321/
https://ncbi.nlm.nih.gov/pubmed/23651857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.212548.112
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