Genome-wide CRISPR-Cas9 screens reveal loss of redundancy between PKMYT1 and WEE1 in Glioblastoma stem-like cells

To identify therapeutic targets for Glioblastoma (GBM), we performed genome-wide CRISPR-Cas9 "knockout" (KO) screens in patient-derived GBM stem-like cells (GSCs) and human neural stem/progenitors (NSCs), non-neoplastic stem cell controls, for genes required for their in vitro growth. Surp...

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Publicado no:Cell Rep
Main Authors: Toledo, Chad M., Ding, Yu, Hoellerbauer, Pia, Davis, Ryan J., Basom, Ryan, Girard, Emily J., Lee, Eunjee, Corrin, Philip, Hart, Traver, Bolouri, Hamid, Davison, Jerry, Zhang, Qing, Hardcastle, Justin, Aronow, Bruce J., Plaisier, Christopher L., Baliga, Nitin S., Moffat, Jason, Lin, Qi, Li, Xiao-Nan, Nam, Do-Hyun, Lee, Jeongwu, Pollard, Steven M., Zhu, Jun, Delrow, Jeffery J., Clurman, Bruce E., Olson, James M., Paddison, Patrick J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4691575/
https://ncbi.nlm.nih.gov/pubmed/26673326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.11.021
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