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Wnt and TGF-β signaling are required for the induction of an in vitro model of primitive streak formation using embryonic stem cells

The establishment of the primitive streak and its derivative germ layers, mesoderm and endoderm, are prerequisite steps in the formation of many tissues. To model these developmental stages in vitro, an ES cell line was established that expresses CD4 from the foxa2 locus in addition to GFP from the...

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Detalhes bibliográficos
Main Authors: Gadue, Paul, Huber, Tara L., Paddison, Patrick J., Keller, Gordon M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1636536/
https://ncbi.nlm.nih.gov/pubmed/17077151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0603916103
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