Screen for reactivation of MeCP2 on the inactive X chromosome identifies the BMP/TGF-β superfamily as a regulator of XIST expression

Rett syndrome (RS) is a debilitating neurological disorder affecting mostly girls with heterozygous mutations in the gene encoding the methyl-CpG–binding protein MeCP2 on the X chromosome. Because restoration of MeCP2 expression in a mouse model reverses neurologic deficits in adult animals, reactiv...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Sripathy, Smitha, Leko, Vid, Adrianse, Robin L., Loe, Taylor, Foss, Eric J., Dalrymple, Emily, Lao, Uyen, Gatbonton-Schwager, Tonibelle, Carter, Kelly T., Payer, Bernhard, Paddison, Patrick J., Grady, William M., Lee, Jeannie T., Bartolomei, Marisa S., Bedalov, Antonio
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5321041/
https://ncbi.nlm.nih.gov/pubmed/28143937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1621356114
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados