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Molecular Pathways: Regulation and Targeting of Kinetochore–Microtubule Attachment in Cancer

Kinetochores are large protein structures assembled on centromeric DNA during mitosis that bind to microtubules of the mitotic spindle to orchestrate and power chromosome movements. Deregulation of kinetochore-microtubule (KT-MT) attachments has been implicated in driving chromosome instability and...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Herman, Jacob A., Toledo, Chad M., Olson, James M., DeLuca, Jennifer G., Paddison, Patrick J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4297562/
https://ncbi.nlm.nih.gov/pubmed/25104085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-0645
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