Cellular aging beyond cellular senescence: Markers of senescence prior to cell cycle arrest in vitro and in vivo

by Ogrodnik, Mikolaj
Published in Aging Cell (2021)

Senescence explains age- and obesity-related liver steatosis

by Ogrodnik, Mikolaj, Jurk, Diana
Published in Cell Stress (2017)

The meaning of adaptation in aging: insights from cellular senescence, epigenetic clocks and stem cell alterations

by Ogrodnik, Mikolaj, Gladyshev, Vadim N.
Published in Nat Aging (2023)

Integrating cellular senescence with the concept of damage accumulation in aging: Relevance for clearance of senescent cells

by Ogrodnik, Mikolaj, Salmonowicz, Hanna, Gladyshev, Vadim N.
Published in Aging Cell (2018)

Simultaneous induction and blockade of autophagy by a single agent

by Kucharewicz, Karolina, Dudkowska, Magdalena, Zawadzka, Anna, Ogrodnik, Mikolaj, Szczepankiewicz, Andrzej A., Czarnocki, Zbigniew, Sikora, Ewa
Published in Cell Death Dis (2018)

Dynamic JUNQ inclusion bodies are asymmetrically inherited in mammalian cell lines through the asymmetric partitioning of vimentin

by Ogrodnik, Mikołaj, Salmonowicz, Hanna, Brown, Rachel, Turkowska, Joanna, Średniawa, Władysław, Pattabiraman, Sundararaghavan, Amen, Triana, Abraham, Ayelet-chen, Eichler, Noam, Lyakhovetsky, Roman, Kaganovich, Daniel
Published 2014

Quercetin Reverses Cardiac Systolic Dysfunction in Mice Fed with a High-Fat Diet: Role of Angiogenesis

by Yu, Shasha, Kim, Seo Rin, Jiang, Kai, Ogrodnik, Mikolaj, Zhu, Xiang Y., Ferguson, Christopher M., Tchkonia, Tamara, Lerman, Amir, Kirkland, James L., Lerman, Lilach O.
Published in Oxid Med Cell Longev (2021)

The bystander effect contributes to the accumulation of senescent cells in vivo

by da Silva, Paulo F. L., Ogrodnik, Mikolaj, Kucheryavenko, Olena, Glibert, Julien, Miwa, Satomi, Cameron, Kerry, Ishaq, Abbas, Saretzki, Gabriele, Nagaraja‐Grellscheid, Sushma, Nelson, Glyn, von Zglinicki, Thomas
Published in Aging Cell (2018)

Increased Renal Cellular Senescence in Murine High-fat Diet: Effect of the Senolytic Drug Quercetin

by Kim, Seo Rin, Jiang, Kai, Ogrodnik, Mikolaj, Chen, Xiaojun, Zhu, Xiang-Yang, Lohmeier, Hannah, Ahmed, Leena, Tang, Hui, Tchkonia, Tamara, Hickson, LaTonya J., Kirkland, James L., Lerman, Lilach O.
Published in Transl Res (2019)

Transplanted Senescent Cells Induce an Osteoarthritis-Like Condition in Mice

by Xu, Ming, Bradley, Elizabeth W., Weivoda, Megan M., Hwang, Soyun M., Pirtskhalava, Tamar, Decklever, Teresa, Curran, Geoffry L., Ogrodnik, Mikolaj, Jurk, Diana, Johnson, Kurt O., Lowe, Val, Tchkonia, Tamar, Westendorf, Jennifer J., Kirkland, James L.
Published in J Gerontol A Biol Sci Med Sci (2017)

JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age

by Xu, Ming, Tchkonia, Tamara, Ding, Husheng, Ogrodnik, Mikolaj, Lubbers, Ellen R., Pirtskhalava, Tamar, White, Thomas A., Johnson, Kurt O., Stout, Michael B., Mezera, Vojtech, Giorgadze, Nino, Jensen, Michael D., LeBrasseur, Nathan K., Kirkland, James L.
Published in Proc Natl Acad Sci U S A (2015)

Identification of Senescent Cells in the Bone Microenvironment

by Farr, Joshua N, Fraser, Daniel G, Wang, Haitao, Jaehn, Katharina, Ogrodnik, Mikolaj B, Weivoda, Megan M, Drake, Matthew T, Tchkonia, Tamara, LeBrasseur, Nathan K, Kirkland, James L, Bonewald, Lynda F, Pignolo, Robert J, Monroe, David G, Khosla, Sundeep
Published in J Bone Miner Res (2016)

Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice

by Roos, Carolyn M., Zhang, Bin, Palmer, Allyson K., Ogrodnik, Mikolaj B., Pirtskhalava, Tamar, Thalji, Nassir M., Hagler, Michael, Jurk, Diana, Smith, Leslie A., Casaclang‐Verzosa, Grace, Zhu, Yi, Schafer, Marissa J., Tchkonia, Tamara, Kirkland, James L., Miller, Jordan D.
Published in Aging Cell (2016)

SQSTM1/p62 mediates crosstalk between autophagy and the UPS in DNA repair

by Hewitt, Graeme, Carroll, Bernadette, Sarallah, Rezazadeh, Correia-Melo, Clara, Ogrodnik, Mikołaj, Nelson, Glyn, Otten, Elsje G., Manni, Diego, Antrobus, Robin, Morgan, Brian A., von Zglinicki, Thomas, Jurk, Diana, Seluanov, Andrei, Gorbunova, Vera, Johansen, Terje, Passos, João F., Korolchuk, Viktor I.
Published in Autophagy (2016)

Senescent human melanocytes drive skin ageing via paracrine telomere dysfunction

by Victorelli, Stella, Lagnado, Anthony, Halim, Jessica, Moore, Will, Talbot, Duncan, Barrett, Karen, Chapman, James, Birch, Jodie, Ogrodnik, Mikolaj, Meves, Alexander, Pawlikowski, Jeff S, Jurk, Diana, Adams, Peter D, van Heemst, Diana, Beekman, Marian, Slagboom, P Eline, Gunn, David A, Passos, João F
Published in EMBO J (2019)

Targeting cellular senescence prevents age-related bone loss in mice

by Farr, Joshua N., Xu, Ming, Weivoda, Megan M., Monroe, David G., Fraser, Daniel G., Onken, Jennifer L., Negley, Brittany A., Sfeir, Jad G., Ogrodnik, Mikolaj B., Hachfeld, Christine M., LeBrasseur, Nathan K., Drake, Matthew T., Pignolo, Robert J., Pirtskhalava, Tamar, Tchkonia, Tamara, Oursler, Merry Jo, Kirkland, James L., Khosla, Sundeep
Published in Nat Med (2017)

Cellular senescence drives age-dependent hepatic steatosis

by Ogrodnik, Mikolaj, Miwa, Satomi, Tchkonia, Tamar, Tiniakos, Dina, Wilson, Caroline L., Lahat, Albert, Day, Christoper P., Burt, Alastair, Palmer, Allyson, Anstee, Quentin M., Grellscheid, Sushma Nagaraja, Hoeijmakers, Jan H J., Barnhoorn, Sander, Mann, Derek A., Bird, Thomas G., Vermeij, Wilbert P., Kirkland, James L., Passos, João F., von Zglinicki, Thomas, Jurk, Diana
Published in Nat Commun (2017)

Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis

by Ogrodnik, Mikolaj, Zhu, Yi, Langhi, Larissa G.P., Tchkonia, Tamar, Krüger, Patrick, Fielder, Edward, Victorelli, Stella, Ruswhandi, Rifqha A., Giorgadze, Nino, Pirtskhalava, Tamar, Podgorni, Oleg, Enikolopov, Grigori, Johnson, Kurt O., Xu, Ming, Inman, Christine, Palmer, Allyson K., Schafer, Marissa, Weigl, Moritz, Ikeno, Yuji, Burns, Terry C., Passos, João F., von Zglinicki, Thomas, Kirkland, James L., Jurk, Diana
Published in Cell Metab (2019)

Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis

by Ogrodnik, Mikolaj, Zhu, Yi, Langhi, Larissa G.P., Tchkonia, Tamar, Krüger, Patrick, Fielder, Edward, Victorelli, Stella, Ruswhandi, Rifqha A., Giorgadze, Nino, Pirtskhalava, Tamar, Podgorni, Oleg, Enikolopov, Grigori, Johnson, Kurt O., Xu, Ming, Inman, Christine, Palmer, Allyson K., Schafer, Marissa, Weigl, Moritz, Ikeno, Yuji, Burns, Terry C., Passos, João F., von Zglinicki, Thomas, Kirkland, James L., Jurk, Diana
Published in Cell Metab (2019)

Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in mice

by Ogrodnik, Mikolaj, Evans, Shane A., Fielder, Edward, Victorelli, Stella, Kruger, Patrick, Salmonowicz, Hanna, Weigand, Bettina M., Patel, Ayush D., Pirtskhalava, Tamar, Inman, Christine L., Johnson, Kurt O., Dickinson, Stephanie L., Rocha, Azucena, Schafer, Marissa J., Zhu, Yi, Allison, David B., von Zglinicki, Thomas, LeBrasseur, Nathan K., Tchkonia, Tamar, Neretti, Nicola, Passos, João F., Kirkland, James L., Jurk, Diana
Published in Aging Cell (2021)