Cockayne Syndrome B protein antagonizes OGG1 in modulating CAG repeat length in vivo

Por Kovtun, Irina V., Johnson, Kurt O., McMurray, Cynthia T.
Publicado em 2011

Transplanted Senescent Cells Induce an Osteoarthritis-Like Condition in Mice

Por Xu, Ming, Bradley, Elizabeth W., Weivoda, Megan M., Hwang, Soyun M., Pirtskhalava, Tamar, Decklever, Teresa, Curran, Geoffry L., Ogrodnik, Mikolaj, Jurk, Diana, Johnson, Kurt O., Lowe, Val, Tchkonia, Tamar, Westendorf, Jennifer J., Kirkland, James L.
Publicado no J Gerontol A Biol Sci Med Sci (2017)

JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age

Por Xu, Ming, Tchkonia, Tamara, Ding, Husheng, Ogrodnik, Mikolaj, Lubbers, Ellen R., Pirtskhalava, Tamar, White, Thomas A., Johnson, Kurt O., Stout, Michael B., Mezera, Vojtech, Giorgadze, Nino, Jensen, Michael D., LeBrasseur, Nathan K., Kirkland, James L.
Publicado no Proc Natl Acad Sci U S A (2015)

Targeting senescent cells enhances adipogenesis and metabolic function in old age

Por Xu, Ming, Palmer, Allyson K, Ding, Husheng, Weivoda, Megan M, Pirtskhalava, Tamar, White, Thomas A, Sepe, Anna, Johnson, Kurt O, Stout, Michael B, Giorgadze, Nino, Jensen, Michael D, LeBrasseur, Nathan K, Tchkonia, Tamar, Kirkland, James L
Publicado no eLife (2015)

Identification of a novel senolytic agent, navitoclax, targeting the Bcl‐2 family of anti‐apoptotic factors

Por Zhu, Yi, Tchkonia, Tamara, Fuhrmann‐Stroissnigg, Heike, Dai, Haiming M., Ling, Yuanyuan Y., Stout, Michael B., Pirtskhalava, Tamar, Giorgadze, Nino, Johnson, Kurt O., Giles, Cory B., Wren, Jonathan D., Niedernhofer, Laura J., Robbins, Paul D., Kirkland, James L.
Publicado no Aging Cell (2016)

Senolytics Improve Physical Function and Increase Lifespan in Old Age

Por Xu, Ming, Pirtskhalava, Tamar, Farr, Joshua N., Weigand, Bettina M., Palmer, Allyson K., Weivoda, Megan M., Inman, Christina L., Ogrodnik, Mikolaj B., Hachfeld, Christine M., Fraser, Daniel G., Onken, Jennifer L., Johnson, Kurt O., Verzosa, Grace C., Langhi, Larissa G. P., Weigl, Moritz, Giorgadze, Nino, LeBrasseur, Nathan K., Miller, Jordan D., Jurk, Diana, Singh, Ravinder J., Allison, David B., Ejima, Keisuke, Hubbard, Gene B., Ikeno, Yuji, Cubro, Hajrunisa, Garovic, Vesna D., Hou, Xiaonan, Weroha, SJ, Robbins, Paul D., Niedernhofer, Laura J., Khosla, Sundeep, Tchkonia, Tamara, Kirkland, James L.
Publicado no Nat Med (2018)