Targeting senescent cells enhances adipogenesis and metabolic function in old age

Senescent cells accumulate in fat with aging. We previously found genetic clearance of senescent cells from progeroid INK-ATTAC mice prevents lipodystrophy. Here we show that primary human senescent fat progenitors secrete activin A and directly inhibit adipogenesis in non-senescent progenitors. Blo...

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Dades bibliogràfiques
Publicat a:eLife
Autors principals: Xu, Ming, Palmer, Allyson K, Ding, Husheng, Weivoda, Megan M, Pirtskhalava, Tamar, White, Thomas A, Sepe, Anna, Johnson, Kurt O, Stout, Michael B, Giorgadze, Nino, Jensen, Michael D, LeBrasseur, Nathan K, Tchkonia, Tamar, Kirkland, James L
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications, Ltd 2015
Matèries:
Developmental Biology and Stem Cells
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4758946/
https://ncbi.nlm.nih.gov/pubmed/26687007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.12997
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