Perspective: Targeting the JAK/STAT pathway to fight age-related dysfunction

由 Xu, Ming, Tchkonia, Tamar, Kirkland, James L.
發表在 Pharmacol Res (2016)

New Horizons: Novel Approaches to Enhance Healthspan Through Targeting Cellular Senescence and Related Aging Mechanisms

由 Tchkonia, Tamar, Palmer, Allyson K, Kirkland, James L
發表在 J Clin Endocrinol Metab (2020)

Senolytics: Potential for Alleviating Diabetes and Its Complications

由 Palmer, Allyson K, Tchkonia, Tamar, Kirkland, James L
發表在 Endocrinology (2021)

Preferential impact of pregnancy-associated plasma protein-A deficiency on visceral fat in mice on high-fat diet

由 Conover, Cheryl A., Harstad, Sara L., Tchkonia, Tamar, Kirkland, James L.
出版 2013

Discovery, development, and future application of senolytics: theories and predictions

由 Wissler Gerdes, Erin O., Zhu, Yi, Tchkonia, Tamar, Kirkland, James L.
發表在 FEBS J (2020)

Markers of cellular senescence are elevated in murine blastocysts cultured in vitro: molecular consequences of culture in atmospheric oxygen

由 Meuter, Alexandra, Rogmann, Lisa-Marlen, Winterhoff, Boris J., Tchkonia, Tamar, Kirkland, James L., Morbeck, Dean E.
出版 2014

Deleted in Breast Cancer 1 Limits Adipose Tissue Fat Accumulation and Plays a Key Role in the Development of Metabolic Syndrome Phenotype

由 Escande, Carlos, Nin, Veronica, Pirtskhalava, Tamar, Chini, Claudia C.S., Tchkonia, Tamar, Kirkland, James L., Chini, Eduardo N.
發表在 Diabetes (2015)

Cellular senescence in aging and age-related diseases: Implications for neurodegenerative diseases

由 Wissler Gerdes, Erin O., Zhu, Yi, Weigand, B. Melanie, Tripathi, Utkarsh, Burns, Terence C., Tchkonia, Tamar, Kirkland, James L.
發表在 Int Rev Neurobiol (2020)

Cellular Senescence Biomarker p16(INK4a)+ Cell Burden in Thigh Adipose is Associated With Poor Physical Function in Older Women

由 Justice, Jamie N, Gregory, Heather, Tchkonia, Tamar, LeBrasseur, Nathan K, Kirkland, James L, Kritchevsky, Stephen B, Nicklas, Barbara J
發表在 J Gerontol A Biol Sci Med Sci (2018)

CELLULAR SENESCENCE AS A THERAPEUTIC TARGET FOR GEROSCIENCE-GUIDED CLINICAL TRIALS

由 Justice, Jamie N, Nambiar, Anoop M, Tchkonia, Tamar, LeBrasseur, Nathan K, Musi, Nicolas, Kritchevsky, Stephen B, Kirkland, James L
發表在 Innov Aging (2019)

The NADase CD38 is induced by factors secreted from senescent cells providing a potential link between senescence and age-related cellular NAD(+) decline.

由 Chini, Claudia C.S., Hogan, Kelly A., Warner, Gina M., Tarragó, Mariana G., Peclat, Thais R., Tchkonia, Tamar, Kirkland, James, Chini, Eduardo N.
發表在 Biochem Biophys Res Commun (2019)

Deleted in Breast Cancer 1 regulates cellular senescence during obesity

由 Escande, Carlos, Nin, Veronica, Pirtskhalava, Tamar, Chini, Claudia C, Thereza Barbosa, Maria, Mathison, Angela, Urrutia, Raul, Tchkonia, Tamar, Kirkland, James L, Chini, Eduardo N
出版 2014

Independent Roles of Estrogen Deficiency and Cellular Senescence in the Pathogenesis of Osteoporosis: Evidence in Young Adult Mice and Older Humans

由 Farr, Joshua N., Rowsey, Jennifer L., Eckhardt, Brittany A., Thicke, Brianne S., Fraser, Daniel G., Tchkonia, Tamar, Kirkland, James L., Monroe, David G., Khosla, Sundeep
發表在 J Bone Miner Res (2019)

Clearance of p16(Ink4a)-positive senescent cells delays ageing-associated disorders

由 Baker, Darren J., Wijshake, Tobias, Tchkonia, Tamar, LeBrasseur, Nathan K., Childs, Bennett G., van de Sluis, Bart, Kirkland, James L., van Deursen, Jan M.
出版 2011

Pathogenesis of Pancreatic Cancer Exosome-Induced Lipolysis in Adipose Tissue

由 Sagar, Gunisha, Sah, Raghuwansh P., Javeed, Naureen, Dutta, Shamit K, Smyrk, Thomas C, Lau, Julie S, Giorgadze, Nino, Tchkonia, Tamar, Kirkland, James, Chari, Suresh T, Mukhopadhyay, Debabrata
發表在 Gut (2015)

Biology of premature ageing in survivors of cancer

由 Cupit-Link, Margaret C, Kirkland, James L, Ness, Kirsten K, Armstrong, Gregory T, Tchkonia, Tamar, LeBrasseur, Nathan K, Armenian, Saro H, Ruddy, Kathryn J, Hashmi, Shahrukh K
發表在 ESMO Open (2017)

Targeted Reduction of Senescent Cell Burden Alleviates Focal Radiotherapy-Related Bone Loss

由 Chandra, Abhishek, Lagnado, Anthony B, Farr, Joshua N, Monroe, David G, Park, Sean, Hachfeld, Christine, Tchkonia, Tamar, Kirkland, James L, Khosla, Sundeep, Passos, João F, Pignolo, Robert J
發表在 J Bone Miner Res (2020)

Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span

由 Robbins, Paul D., Jurk, Diana, Khosla, Sundeep, Kirkland, James L., LeBrasseur, Nathan K., Miller, Jordan D., Passos, João F., Pignolo, Robert J., Tchkonia, Tamar, Niedernhofer, Laura J.
發表在 Annu Rev Pharmacol Toxicol (2020)

Premature Physiologic Aging as a Paradigm for Understanding Increased Risk of Adverse Health Across the Lifespan of Survivors of Childhood Cancer

由 Ness, Kirsten K., Kirkland, James L., Gramatges, Maria Monica, Wang, Zhaoming, Kundu, Mondira, McCastlain, Kelly, Li-Harms, Xiujie, Zhang, Jinghui, Tchkonia, Tamar, Pluijm, Saskia Martine Francesca, Armstrong, Gregory T.
發表在 J Clin Oncol (2018)

Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study

由 Justice, Jamie N., Nambiar, Anoop M., Tchkonia, Tamar, LeBrasseur, Nathan K., Pascual, Rodolfo, Hashmi, Shahrukh K., Prata, Larissa, Masternak, Michal M., Kritchevsky, Stephen B., Musi, Nicolas, Kirkland, James L.
發表在 EBioMedicine (2019)