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The NADase CD38 is induced by factors secreted from senescent cells providing a potential link between senescence and age-related cellular NAD(+) decline.
Tissue nicotinamide adenine dinucleotide (NAD(+)) decline has been implicated in aging. We have recently identified CD38 as a central regulator involved in tissue NAD(+) decline during the aging process. CD38 is an ecto-enzyme highly expressed in endothelial and inflammatory cells. To date, the mech...
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| Publicado no: | Biochem Biophys Res Commun |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6486859/ https://ncbi.nlm.nih.gov/pubmed/30975470 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2019.03.199 |
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