CD38 dictates age-related NAD decline and mitochondrial dysfunction through a SIRT3-dependent mechanism

Nicotinamide Adenine Dinucleotide (NAD) levels decrease during aging, and are involved in age-related metabolic decline. To date, the mechanism responsible for the age-related reduction in NAD has not been elucidated. Here we demonstrate that expression and activity of the NADase CD38 increase with...

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Detalhes bibliográficos
Publicado no:Cell Metab
Main Authors: Camacho-Pereira, Juliana, Tarragó, Mariana G., Chini, Claudia C.S., Nin, Veronica, Escande, Carlos, Warner, Gina M., Puranik, Amrutesh S., Schoon, Renee A., Reid, Joel M., Galina, Antonio, Chini, Eduardo N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4911708/
https://ncbi.nlm.nih.gov/pubmed/27304511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2016.05.006
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