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Discovery, development, and future application of senolytics: theories and predictions

Senescent cells accumulate with aging and at etiological sites of multiple diseases, including those accounting for most morbidity, mortality, and health costs. Senescent cells do not replicate, can release factors that cause tissue dysfunction, and yet remain viable. The discovery of senolytic drug...

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Опубликовано в: :FEBS J
Главные авторы: Wissler Gerdes, Erin O., Zhu, Yi, Tchkonia, Tamar, Kirkland, James L.
Формат: Artigo
Язык:Inglês
Опубликовано: John Wiley and Sons Inc. 2020
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7302972/
https://ncbi.nlm.nih.gov/pubmed/32112672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/febs.15264
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