Growth hormone in adipose dysfunction and senescence

Por Stout, Michael B., Tchkonia, Tamara, Kirkland, James L.
Publicado no Oncotarget (2015)

Physiological Aging: Links Among Adipose Tissue Dysfunction, Diabetes, and Frailty

Por Stout, Michael B., Justice, Jamie N., Nicklas, Barbara J., Kirkland, James L.
Publicado no Physiology (Bethesda) (2016)

Butyrylcholinesterase Deficiency Promotes Adipose Tissue Growth and Hepatic Lipid Accumulation in Male Mice on High-Fat Diet

Por Chen, Vicky Ping, Gao, Yang, Geng, Liyi, Stout, Michael B., Jensen, Michael D., Brimijoin, Stephen
Publicado no Endocrinology (2016)

Evaluating Health Span in Preclinical Models of Aging and Disease: Guidelines, Challenges, and Opportunities for Geroscience

Por Huffman, Derek M., Justice, Jamie N., Stout, Michael B., Kirkland, James L., Barzilai, Nir, Austad, Steven N.
Publicado no J Gerontol A Biol Sci Med Sci (2016)

Development of a high‐throughput method for real‐time assessment of cellular metabolism in intact long skeletal muscle fibre bundles

Por Li, Rui, Steyn, Frederik J., Stout, Michael B., Lee, Kevin, Cully, Tanya R., Calderón, Juan C., Ngo, Shyuan T.
Publicado no J Physiol (2016)

Short-term food restriction followed by controlled refeeding promotes gorging behavior, enhances fat deposition, and diminishes insulin sensitivity in mice

Por Kliewer, Kara L., Ke, Jia-Yu, Stout, Michael B., Cole, Rachel, Samuel, Varman T., Shulman, Gerald I., Belury, Martha A.
Publicado no J Nutr Biochem (2015)

Short-Term Aerobic Exercise Training in Obese Humans with Type 2 Diabetes Mellitus Improves Whole-Body Insulin Sensitivity through Gains in Peripheral, not Hepatic Insulin Sensitiv...

Por Winnick, Jason J., Sherman, W. Michael, Habash, Diane L., Stout, Michael B., Failla, Mark L., Belury, Martha A., Schuster, Dara P.
Publicado em 2008

Retinal gene expression responses to aging are sexually divergent

Por Du, Mei, Mangold, Colleen A., Bixler, Georgina V., Brucklacher, Robert M., Masser, Dustin R., Stout, Michael B., Elliott, Michael H., Freeman, Willard M.
Publicado no Mol Vis (2017)

Time-dependent effects of safflower oil to improve glycemia, inflammation and blood lipids in obese, post-menopausal women with type 2 diabetes: a randomized, double-masked, crosso...

Por Asp, Michelle L., Collene, Angela L., Norris, Leigh E., Cole, Rachel M., Stout, Michael B., Tang, Szu-Yu, Hsu, Jason C., Belury, Martha A.
Publicado em 2011

Gene expression of key regulators of mitochondrial biogenesis is sex dependent in mice with growth hormone receptor deletion in liver

Por Zawada, Ilona, Masternak, Michal M., List, Edward O., Stout, Michael B., Berryman, Darlene E., Lewinski, Andrzej, Kopchick, John J., Bartke, Andrzej, Karbownik-Lewinska, Malgorzata, Gesing, Adam
Publicado no Aging (Albany NY) (2015)

Transcriptome profiling reveals divergent expression shifts in brown and white adipose tissue from long-lived GHRKO mice

Por Stout, Michael B., Swindell, William R., Zhi, Xu, Rohde, Kyle, List, Edward O., Berryman, Darlene E., Kopchick, John J., Gesing, Adam, Fang, Yimin, Masternak, Michal M.
Publicado no Oncotarget (2015)

Inflammation and the Depot-Specific Secretome of Human Preadipocytes

Por Zhu, Yi, Tchkonia, Tamara, Stout, Michael B., Giorgadze, Nino, Wang, Libing, Li, Peter W., Heppelmann, Carrie J., Bouloumié, Anne, Jensen, Michael D., Bergen, H. Robert, Kirkland, James L.
Publicado no Obesity (Silver Spring) (2015)

JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age

Por Xu, Ming, Tchkonia, Tamara, Ding, Husheng, Ogrodnik, Mikolaj, Lubbers, Ellen R., Pirtskhalava, Tamar, White, Thomas A., Johnson, Kurt O., Stout, Michael B., Mezera, Vojtech, Giorgadze, Nino, Jensen, Michael D., LeBrasseur, Nathan K., Kirkland, James L.
Publicado no Proc Natl Acad Sci U S A (2015)

Removal of growth hormone receptor (GHR) in muscle of male mice replicates some of the health benefits seen in global GHR−/− mice

Por List, Edward O., Berryman, Darlene E., Ikeno, Yuji, Hubbard, Gene B., Funk, Kevin, Comisford, Ross, Young, Jonathan A., Stout, Michael B., Tchkonia, Tamar, Masternak, Michal M., Bartke, Andrzej, Kirkland, James L., Miller, Richard A., Kopchick, John J.
Publicado no Aging (Albany NY) (2015)

Targeting senescent cells enhances adipogenesis and metabolic function in old age

Por Xu, Ming, Palmer, Allyson K, Ding, Husheng, Weivoda, Megan M, Pirtskhalava, Tamar, White, Thomas A, Sepe, Anna, Johnson, Kurt O, Stout, Michael B, Giorgadze, Nino, Jensen, Michael D, LeBrasseur, Nathan K, Tchkonia, Tamar, Kirkland, James L
Publicado no eLife (2015)

Identification of a novel senolytic agent, navitoclax, targeting the Bcl‐2 family of anti‐apoptotic factors

Por Zhu, Yi, Tchkonia, Tamara, Fuhrmann‐Stroissnigg, Heike, Dai, Haiming M., Ling, Yuanyuan Y., Stout, Michael B., Pirtskhalava, Tamar, Giorgadze, Nino, Johnson, Kurt O., Giles, Cory B., Wren, Jonathan D., Niedernhofer, Laura J., Robbins, Paul D., Kirkland, James L.
Publicado no Aging Cell (2016)

Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in mice

Por Stout, Michael B., Tchkonia, Tamara, Pirtskhalava, Tamar, Palmer, Allyson K., List, Edward O., Berryman, Darlene E., Lubbers, Ellen R., Escande, Carlos, Spong, Adam, Masternak, Michal M., Oberg, Ann L., LeBrasseur, Nathan K., Miller, Richard A., Kopchick, John J., Bartke, Andrzej, Kirkland, James L.
Publicado em 2014

TRAIL RECEPTOR DELETION IN MICE SUPPRESSES THE INFLAMMATION OF NUTRIENT EXCESS

Por Idrissova, Leila, Malhi, Harmeet, Werneburg, Nathan W., LeBrasseur, Nathan K., Bronk, Steve F., Fingas, Christian, Tchkonia, Tamar, Pirtskhalava, Tamar, White, Thomas A., Stout, Michael B., Hirsova, Petra, Krishnan, Anuradha, Liedtke, Christian, Trautwein, Christian, Finnberg, Niklas, El-Deiry, Wafik S., Kirkland, James L., Gores, Gregory J.
Publicado no J Hepatol (2014)

Exercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue

Por Schafer, Marissa J., White, Thomas A., Evans, Glenda, Tonne, Jason M., Verzosa, Grace C., Stout, Michael B., Mazula, Daniel L., Palmer, Allyson K., Baker, Darren J., Jensen, Michael D., Torbenson, Michael S., Miller, Jordan D., Ikeda, Yasuhiro, Tchkonia, Tamara, van Deursen, Jan M., Kirkland, James L., LeBrasseur, Nathan K.
Publicado no Diabetes (2016)

Liver-Specific GH Receptor Gene-Disrupted (LiGHRKO) Mice Have Decreased Endocrine IGF-I, Increased Local IGF-I, and Altered Body Size, Body Composition, and Adipokine Profiles

Por List, Edward O., Berryman, Darlene E., Funk, Kevin, Jara, Adam, Kelder, Bruce, Wang, Feiya, Stout, Michael B., Zhi, Xu, Sun, Liou, White, Thomas A., LeBrasseur, Nathan K., Pirtskhalava, Tamara, Tchkonia, Tamara, Jensen, Elizabeth A., Zhang, Wenjuan, Masternak, Michal M., Kirkland, James L., Miller, Richard A., Bartke, Andrzej, Kopchick, John J.
Publicado em 2014