Liver-Specific GH Receptor Gene-Disrupted (LiGHRKO) Mice Have Decreased Endocrine IGF-I, Increased Local IGF-I, and Altered Body Size, Body Composition, and Adipokine Profiles

GH is an important regulator of body growth and composition as well as numerous other metabolic processes. In particular, liver plays a key role in the GH/IGF-I axis, because the majority of circulating “endocrine” IGF-I results from GH-stimulated liver IGF-I production. To develop a better understa...

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Main Authors: List, Edward O., Berryman, Darlene E., Funk, Kevin, Jara, Adam, Kelder, Bruce, Wang, Feiya, Stout, Michael B., Zhi, Xu, Sun, Liou, White, Thomas A., LeBrasseur, Nathan K., Pirtskhalava, Tamara, Tchkonia, Tamara, Jensen, Elizabeth A., Zhang, Wenjuan, Masternak, Michal M., Kirkland, James L., Miller, Richard A., Bartke, Andrzej, Kopchick, John J.
Format: Artigo
Jezik:Inglês
Izdano: Endocrine Society 2014
Teme:
Growth Hormone-Somatostatin-GRH
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3990850/
https://ncbi.nlm.nih.gov/pubmed/24517230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2013-2086
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