Liver-Specific GH Receptor Gene-Disrupted (LiGHRKO) Mice Have Decreased Endocrine IGF-I, Increased Local IGF-I, and Altered Body Size, Body Composition, and Adipokine Profiles

GH is an important regulator of body growth and composition as well as numerous other metabolic processes. In particular, liver plays a key role in the GH/IGF-I axis, because the majority of circulating “endocrine” IGF-I results from GH-stimulated liver IGF-I production. To develop a better understa...

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Bibliografiske detaljer
Main Authors: List, Edward O., Berryman, Darlene E., Funk, Kevin, Jara, Adam, Kelder, Bruce, Wang, Feiya, Stout, Michael B., Zhi, Xu, Sun, Liou, White, Thomas A., LeBrasseur, Nathan K., Pirtskhalava, Tamara, Tchkonia, Tamara, Jensen, Elizabeth A., Zhang, Wenjuan, Masternak, Michal M., Kirkland, James L., Miller, Richard A., Bartke, Andrzej, Kopchick, John J.
Format: Artigo
Sprog:Inglês
Udgivet: Endocrine Society 2014
Fag:
Growth Hormone-Somatostatin-GRH
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3990850/
https://ncbi.nlm.nih.gov/pubmed/24517230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2013-2086
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