Removal of growth hormone receptor (GHR) in muscle of male mice replicates some of the health benefits seen in global GHR−/− mice

Global disruption of the GH receptor in mice (GHR−/−) produces a large and reproducible extension in lifespan. Since lack of GH action in muscle resulting in improved glucose homeostasis is potentially a mechanism by which GHR−/− mice are long-lived, and since no information on muscle-specific GHR d...

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Detalhes bibliográficos
Publicado no:Aging (Albany NY)
Main Authors: List, Edward O., Berryman, Darlene E., Ikeno, Yuji, Hubbard, Gene B., Funk, Kevin, Comisford, Ross, Young, Jonathan A., Stout, Michael B., Tchkonia, Tamar, Masternak, Michal M., Bartke, Andrzej, Kirkland, James L., Miller, Richard A., Kopchick, John J.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4543039/
https://ncbi.nlm.nih.gov/pubmed/26233957
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