Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in mice

Cellular senescence is characterized by an irreversible cell cycle arrest and a pro‐inflammatory senescence‐associated secretory phenotype (SASP), which is a major contributor to aging and age‐related diseases. Clearance of senescent cells has been shown to improve brain function in mouse models of...

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Publicado en:Aging Cell
Autores principales: Ogrodnik, Mikolaj, Evans, Shane A., Fielder, Edward, Victorelli, Stella, Kruger, Patrick, Salmonowicz, Hanna, Weigand, Bettina M., Patel, Ayush D., Pirtskhalava, Tamar, Inman, Christine L., Johnson, Kurt O., Dickinson, Stephanie L., Rocha, Azucena, Schafer, Marissa J., Zhu, Yi, Allison, David B., von Zglinicki, Thomas, LeBrasseur, Nathan K., Tchkonia, Tamar, Neretti, Nicola, Passos, João F., Kirkland, James L., Jurk, Diana
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2021
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Original Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7884042/
https://ncbi.nlm.nih.gov/pubmed/33470505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.13296
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