Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice

While reports suggest a single dose of senolytics may improve vasomotor function, the structural and functional impact of long‐term senolytic treatment is unknown. To determine whether long‐term senolytic treatment improves vasomotor function, vascular stiffness, and intimal plaque size and composit...

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Dettagli Bibliografici
Pubblicato in:Aging Cell
Autori principali: Roos, Carolyn M., Zhang, Bin, Palmer, Allyson K., Ogrodnik, Mikolaj B., Pirtskhalava, Tamar, Thalji, Nassir M., Hagler, Michael, Jurk, Diana, Smith, Leslie A., Casaclang‐Verzosa, Grace, Zhu, Yi, Schafer, Marissa J., Tchkonia, Tamara, Kirkland, James L., Miller, Jordan D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2016
Soggetti:
Short Takes
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5013022/
https://ncbi.nlm.nih.gov/pubmed/26864908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12458
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