Identification of Senescent Cells in the Bone Microenvironment

Cellular senescence is a fundamental mechanism by which cells remain metabolically active yet cease dividing and undergo distinct phenotypic alterations, including upregulation of p16(Ink4a), profound secretome changes, telomere shortening, and decondensation of pericentromeric satellite DNA. Becaus...

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Detalhes bibliográficos
Publicado no:J Bone Miner Res
Main Authors: Farr, Joshua N, Fraser, Daniel G, Wang, Haitao, Jaehn, Katharina, Ogrodnik, Mikolaj B, Weivoda, Megan M, Drake, Matthew T, Tchkonia, Tamara, LeBrasseur, Nathan K, Kirkland, James L, Bonewald, Lynda F, Pignolo, Robert J, Monroe, David G, Khosla, Sundeep
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5289710/
https://ncbi.nlm.nih.gov/pubmed/27341653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.2892
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