Targeting cellular senescence prevents age-related bone loss in mice

Aging is associated with increased cellular senescence, which is hypothesized to drive the eventual development of multiple co-morbidities(1). Here, we investigate a role for senescent cells in age-related bone loss by multiple approaches. In particular, we used either genetic (i.e., the INK-ATTAC “...

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Publicado no:Nat Med
Main Authors: Farr, Joshua N., Xu, Ming, Weivoda, Megan M., Monroe, David G., Fraser, Daniel G., Onken, Jennifer L., Negley, Brittany A., Sfeir, Jad G., Ogrodnik, Mikolaj B., Hachfeld, Christine M., LeBrasseur, Nathan K., Drake, Matthew T., Pignolo, Robert J., Pirtskhalava, Tamar, Tchkonia, Tamara, Oursler, Merry Jo, Kirkland, James L., Khosla, Sundeep
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5657592/
https://ncbi.nlm.nih.gov/pubmed/28825716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4385
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