Targeting cellular senescence prevents age-related bone loss in mice

Aging is associated with increased cellular senescence, which is hypothesized to drive the eventual development of multiple co-morbidities(1). Here, we investigate a role for senescent cells in age-related bone loss by multiple approaches. In particular, we used either genetic (i.e., the INK-ATTAC “...

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Publicado en:Nat Med
Autores principales: Farr, Joshua N., Xu, Ming, Weivoda, Megan M., Monroe, David G., Fraser, Daniel G., Onken, Jennifer L., Negley, Brittany A., Sfeir, Jad G., Ogrodnik, Mikolaj B., Hachfeld, Christine M., LeBrasseur, Nathan K., Drake, Matthew T., Pignolo, Robert J., Pirtskhalava, Tamar, Tchkonia, Tamara, Oursler, Merry Jo, Kirkland, James L., Khosla, Sundeep
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5657592/
https://ncbi.nlm.nih.gov/pubmed/28825716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4385
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