Fast Protein Translation Can Promote Co- and Posttranslational Folding of Misfolding-Prone Proteins

Por Trovato, Fabio, O’Brien, Edward P.
Publicado no Biophys J (2017)

Altered Co-Translational Processing Plays a Role in Huntington's Pathogenesis—A Hypothesis

Por Nissley, Daniel A., O'Brien, Edward P.
Publicado no Front Mol Neurosci (2016)

Effects of pH on proteins: Predictions for ensemble and single molecule pulling experiments

Por O’Brien, Edward P., Brooks, Bernard R., Thirumalai, D.
Publicado em 2011

Molecular origin of constant m-values, denatured state collapse, and residue-dependent transition midpoints in globular proteins

Por O’Brien, Edward P., Brooks, Bernard R., Thirumalai, D.
Publicado no Biochemistry (2009)

Collapse kinetics and chevron plots from simulations of denaturant-dependent folding of globular proteins

Por Liu, Zhenxing, Reddy, Govardhan, O’Brien, Edward P., Thirumalai, D.
Publicado em 2011

Factors governing helix formation in peptides confined to carbon nanotubes

Por O’Brien, Edward P., Stan, George, Thirumalai, D., Brooks, Bernard R.
Publicado em 2008

How accurate are polymer models in the analysis of Förster resonance energy transfer experiments on proteins?

Por O’Brien, Edward P., Morrison, Greg, Brooks, Bernard R., Thirumalai, D.
Publicado em 2009

Influence of Nanoparticle Size and Shape on Oligomer Formation of an Amyloidogenic Peptide

Por O'Brien, Edward P., Straub, John. E., Brooks, Bernard R., Thirumalai, D.
Publicado em 2011

Effects of denaturants and osmolytes on proteins are accurately predicted by the molecular transfer model

Por O'Brien, Edward P., Ziv, Guy, Haran, Gilad, Brooks, Bernard R., Thirumalai, D.
Publicado em 2008

Erythromycin leads to differential protein expression through differences in electrostatic and dispersion interactions with nascent proteins

Por Nguyen, Hoang Linh, Pham, Dang Lan, O’Brien, Edward P., Li, Mai Suan
Publicado no Sci Rep (2018)

In vivo translation rates can substantially delay the cotranslational folding of the Escherichia coli cytosolic proteome

Por Ciryam, Prajwal, Morimoto, Richard I., Vendruscolo, Michele, Dobson, Christopher M., O’Brien, Edward P.
Publicado em 2013

A thermodynamic perspective on the dock-lock growth mechanism of amyloid fibrils

Por O’Brien, Edward P., Okamoto, Yuko, Straub, John. E., Brooks, Bernard R., Thirumalai, D.
Publicado em 2009

Kinetic and structural comparison of a protein’s cotranslational folding and refolding pathways

Por Samelson, Avi J., Bolin, Eric, Costello, Shawn M., Sharma, Ajeet K., O’Brien, Edward P., Marqusee, Susan
Publicado no Sci Adv (2018)

Origins of the mechanochemical coupling of peptide bond formation to protein synthesis

Por Fritch, Benjamin, Kosolapov, Andrey, Hudson, Phillip, Nissley, Daniel A., Woodcock, H. Lee, Deutsch, Carol, O’Brien, Edward P.
Publicado no J Am Chem Soc (2018)

Accurate prediction of cellular co-translational folding indicates proteins can switch from post- to co-translational folding

Por Nissley, Daniel A., Sharma, Ajeet K., Ahmed, Nabeel, Friedrich, Ulrike A., Kramer, Günter, Bukau, Bernd, O'Brien, Edward P.
Publicado no Nat Commun (2016)

Cotranslational Protein Folding inside the Ribosome Exit Tunnel

Por Nilsson, Ola B., Hedman, Rickard, Marino, Jacopo, Wickles, Stephan, Bischoff, Lukas, Johansson, Magnus, Müller-Lucks, Annika, Trovato, Fabio, Puglisi, Joseph D., O’Brien, Edward P., Beckmann, Roland, von Heijne, Gunnar
Publicado no Cell Rep (2015)

Hermansky-Pudlak syndrome type 7 (HPS-7) results from mutant dysbindin, a member of the biogenesis of lysosome-related organelles complex 1 (BLOC-1)

Por Li, Wei, Zhang, Qing, Oiso, Naoki, Novak, Edward K, Gautam, Rashi, O'Brien, Edward P, Tinsley, Caroline L, Blake, Derek J, Spritz, Richard A, Copeland, Neal G, Jenkins, Nancy A, Amato, Dominick, Roe, Bruce A, Starcevic, Marta, Dell'Angelica, Esteban C, Elliott, Rosemary W, Mishra, Vishnu, Kingsmore, Stephen F, Paylor, Richard E, Swank, Richard T
Publicado em 2003