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Effects of denaturants and osmolytes on proteins are accurately predicted by the molecular transfer model

Interactions between denaturants and proteins are commonly used to probe the structures of the denatured state ensemble and their stabilities. Osmolytes, a class of small intracellular organic molecules found in all taxa, also profoundly affect the equilibrium properties of proteins. We introduce th...

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Autori principali: O'Brien, Edward P., Ziv, Guy, Haran, Gilad, Brooks, Bernard R., Thirumalai, D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2533202/
https://ncbi.nlm.nih.gov/pubmed/18757747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0802113105
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