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Fast Protein Translation Can Promote Co- and Posttranslational Folding of Misfolding-Prone Proteins

Chemical kinetic modeling has previously been used to predict that fast-translating codons can enhance cotranslational protein folding by helping to avoid misfolded intermediates. Consistent with this prediction, protein aggregation in yeast and worms was observed to increase when translation was gl...

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Библиографические подробности
Опубликовано в: :Biophys J
Главные авторы: Trovato, Fabio, O’Brien, Edward P.
Формат: Artigo
Язык:Inglês
Опубликовано: The Biophysical Society 2017
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5425611/
https://ncbi.nlm.nih.gov/pubmed/28494952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2017.04.006
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