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Fast Protein Translation Can Promote Co- and Posttranslational Folding of Misfolding-Prone Proteins
Chemical kinetic modeling has previously been used to predict that fast-translating codons can enhance cotranslational protein folding by helping to avoid misfolded intermediates. Consistent with this prediction, protein aggregation in yeast and worms was observed to increase when translation was gl...
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| Yayımlandı: | Biophys J |
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| Asıl Yazarlar: | , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
The Biophysical Society
2017
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5425611/ https://ncbi.nlm.nih.gov/pubmed/28494952 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2017.04.006 |
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