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Cotranslational folding allows misfolding-prone proteins to circumvent deep kinetic traps
Many large proteins suffer from slow or inefficient folding in vitro. It has long been known that this problem can be alleviated in vivo if proteins start folding cotranslationally. However, the molecular mechanisms underlying this improvement have not been well established. To address this question...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6983386/ https://ncbi.nlm.nih.gov/pubmed/31911473 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1913207117 |
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