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Hidden kinetic traps in multidomain folding highlight the presence of a misfolded but functionally competent intermediate
Although more than 75% of the proteome is composed of multidomain proteins, current knowledge of protein folding is based primarily on studies of isolated domains. In this work, we describe the folding mechanism of a multidomain tandem construct comprising two distinct covalently bound PDZ domains b...
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| Vydáno v: | Proc Natl Acad Sci U S A |
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| Hlavní autoři: | , , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
2020
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7443948/ https://ncbi.nlm.nih.gov/pubmed/32747559 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2004138117 |
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