Hidden kinetic traps in multidomain folding highlight the presence of a misfolded but functionally competent intermediate

Although more than 75% of the proteome is composed of multidomain proteins, current knowledge of protein folding is based primarily on studies of isolated domains. In this work, we describe the folding mechanism of a multidomain tandem construct comprising two distinct covalently bound PDZ domains b...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Gautier, Candice, Troilo, Francesca, Cordier, Florence, Malagrinò, Francesca, Toto, Angelo, Visconti, Lorenzo, Zhu, Yanlei, Brunori, Maurizio, Wolff, Nicolas, Gianni, Stefano
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7443948/
https://ncbi.nlm.nih.gov/pubmed/32747559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2004138117
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