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Cotranslational folding allows misfolding-prone proteins to circumvent deep kinetic traps
Many large proteins suffer from slow or inefficient folding in vitro. It has long been known that this problem can be alleviated in vivo if proteins start folding cotranslationally. However, the molecular mechanisms underlying this improvement have not been well established. To address this question...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6983386/ https://ncbi.nlm.nih.gov/pubmed/31911473 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1913207117 |
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