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Cotranslational folding allows misfolding-prone proteins to circumvent deep kinetic traps
Many large proteins suffer from slow or inefficient folding in vitro. It has long been known that this problem can be alleviated in vivo if proteins start folding cotranslationally. However, the molecular mechanisms underlying this improvement have not been well established. To address this question...
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| Publicado en: | Proc Natl Acad Sci U S A |
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| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
2020
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6983386/ https://ncbi.nlm.nih.gov/pubmed/31911473 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1913207117 |
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