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Cotranslational folding allows misfolding-prone proteins to circumvent deep kinetic traps

Many large proteins suffer from slow or inefficient folding in vitro. It has long been known that this problem can be alleviated in vivo if proteins start folding cotranslationally. However, the molecular mechanisms underlying this improvement have not been well established. To address this question...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Bitran, Amir, Jacobs, William M., Zhai, Xiadi, Shakhnovich, Eugene
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2020
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6983386/
https://ncbi.nlm.nih.gov/pubmed/31911473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1913207117
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