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Fast Protein Translation Can Promote Co- and Posttranslational Folding of Misfolding-Prone Proteins
Chemical kinetic modeling has previously been used to predict that fast-translating codons can enhance cotranslational protein folding by helping to avoid misfolded intermediates. Consistent with this prediction, protein aggregation in yeast and worms was observed to increase when translation was gl...
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| 出版年: | Biophys J |
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| 主要な著者: | , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
The Biophysical Society
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5425611/ https://ncbi.nlm.nih.gov/pubmed/28494952 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2017.04.006 |
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