Emerging roles of the neural adaptor FE65 in neurite outgrowth

Por Li, Wen, Chan, Wai Wa Ray, Ngo, Jacky Chi Ki, Lau, Kwok-Fai
Publicado no Neural Regen Res (2018)

Crystal Structures of Matriptase in Complex with Its Inhibitor Hepatocyte Growth Factor Activator Inhibitor-1

Por Zhao, Baoyu, Yuan, Cai, Li, Rui, Qu, Dan, Huang, Mingdong, Ngo, Jacky Chi Ki
Publicado em 2013

Allosteric Interactions Direct Binding and Phosphorylation of ASF/SF2 by SRPK1

Por Huynh, Nhat, Ma, Chen-Ting, Giang, Ngoc, Hagopian, Jonathan, Ngo, Jacky, Adams, Joseph, Ghosh, Gourisankar
Publicado em 2009

Structure of catalytic domain of Matriptase in complex with Sunflower trypsin inhibitor-1

Por Yuan, Cai, Chen, Liqing, Meehan, Edward J, Daly, Norelle, Craik, David J, Huang, Mingdong, Ngo, Jacky C
Publicado em 2011

GULP1/CED-6 ameliorates amyloid-β toxicity in a Drosophila model of Alzheimer’s disease

Por Vivien Chiu, Wai Yin, Koon, Alex Chun, Ki Ngo, Jacky Chi, Edwin Chan, Ho Yin, Lau, Kwok-Fai
Publicado no Oncotarget (2017)

Processive phosphorylation of alternative splicing factor/splicing factor 2

Por Aubol, Brandon E., Chakrabarti, Sutapa, Ngo, Jacky, Shaffer, Jennifer, Nolen, Brad, Fu, Xiang-Dong, Ghosh, Gourisankar, Adams, Joseph A.
Publicado em 2003

A Peptidylic Inhibitor for Neutralizing (r)(GGGGCC)(exp)-Associated Neurodegeneration in C9ALS-FTD

Por Zhang, Qian, An, Ying, Chen, Zhefan Stephen, Koon, Alex Chun, Lau, Kwok-Fai, Ngo, Jacky Chi Ki, Chan, Ho Yin Edwin
Publicado no Mol Ther Nucleic Acids (2019)

Assessing a peptidylic inhibitor-based therapeutic approach that simultaneously suppresses polyglutamine RNA- and protein-mediated toxicities in patient cells and Drosophila

Por Zhang, Qian, Tsoi, Ho, Peng, Shaohong, Li, Pan P., Lau, Kwok-Fai, Rudnicki, Dobrila D., Ngo, Jacky Chi-Ki, Chan, Ho Yin Edwin
Publicado no Dis Model Mech (2016)

Neuronal adaptor FE65 stimulates Rac1-mediated neurite outgrowth by recruiting and activating ELMO1

Por Li, Wen, Tam, Ka Ming Vincent, Chan, Wai Wa Ray, Koon, Alex Chun, Ngo, Jacky Chi Ki, Chan, Ho Yin Edwin, Lau, Kwok-Fai
Publicado no J Biol Chem (2018)

Adaptable Molecular Interactions Guide Phosphorylation of the SR Protein ASF/SF2 By SRPK1

Por Hagopian, Jonathan C., Ma, Chen-Ting, Meade, Bryan R., Albuquerque, Claudio P., Ngo, Jacky C., Ghosh, Gourisankar, Jennings, Patricia A., Fu, Xiang-Dong, Adams, Joseph A.
Publicado em 2008

A Camelid-derived Antibody Fragment Targeting the Active Site of a Serine Protease Balances between Inhibitor and Substrate Behavior

Por Kromann-Hansen, Tobias, Oldenburg, Emil, Yung, Kristen Wing Yu, Ghassabeh, Gholamreza H., Muyldermans, Serge, Declerck, Paul J., Huang, Mingdong, Andreasen, Peter A., Ngo, Jacky Chi Ki
Publicado no J Biol Chem (2016)

A peptidylic inhibitor for neutralizing expanded CAG RNA-induced nucleolar stress in polyglutamine diseases

Por Zhang, Qian, Chen, Zhefan Stephen, An, Ying, Liu, Haizhen, Hou, Yonghui, Li, Wen, Lau, Kwok-Fai, Koon, Alex Chun, Ngo, Jacky Chi Ki, Chan, Ho Yin Edwin
Publicado no RNA (2018)

Attenuation of amyloid-β generation by atypical protein kinase C–mediated phosphorylation of engulfment adaptor PTB domain containing 1 threonine 35

Por Chau, Dennis Dik-Long, Yung, Kristen Wing-Yu, Chan, William Wai-Lun, An, Ying, Hao, Yan, Chan, Ho-Yin Edwin, Ngo, Jacky Chi-Ki, Lau, Kwok-Fai
Publicado no FASEB J (2019)

A Sliding Docking Interaction Is Essential for Sequential and Processive Phosphorylation of an SR Protein by SRPK1

Por Ngo, Jacky Chi Ki, Giang, Kayla, Chakrabarti, Sutapa, Ma, Chen-Ting, Huynh, Nhat, Hagopian, Jonathan C., Dorrestein, Pieter C., Fu, Xiang-Dong, Adams, Joseph A., Ghosh, Gourisankar
Publicado em 2008

Phosphorylation of FE65 Ser(610) by serum- and glucocorticoid-induced kinase 1 modulates Alzheimer's disease amyloid precursor protein processing

Por Chow, Wan Ning Vanessa, Ngo, Jacky Chi Ki, Li, Wen, Chen, Yu Wai, Tam, Ka Ming Vincent, Chan, Ho Yin Edwin, Miller, Christopher C.J., Lau, Kwok-Fai
Publicado no Biochem J (2015)

Identification of influenza polymerase inhibitors targeting C-terminal domain of PA through surface plasmon resonance screening

Por Lo, Chun-Yeung, Li, Olive Tin-Wai, Tang, Wen-Ping, Hu, Chun, Wang, Guo Xin, Ngo, Jacky Chi-Ki, Wan, David Chi-Cheong, Poon, Leo Lit-Man, Shaw, Pang-Chui
Publicado no Sci Rep (2018)

A brain-targeting lipidated peptide for neutralizing RNA-mediated toxicity in Polyglutamine Diseases

Por Zhang, Qian, Yang, Mengbi, Sørensen, Kasper K., Madsen, Charlotte S., Boesen, Josephine T., An, Ying, Peng, Shao Hong, Wei, Yuming, Wang, Qianwen, Jensen, Knud J., Zuo, Zhong, Chan, Ho Yin Edwin, Ngo, Jacky Chi Ki
Publicado no Sci Rep (2017)

Distinct mechanisms govern the phosphorylation of different SR protein splicing factors

Por Long, Yunxin, Sou, Weng Hong, Yung, Kristen Wing Yu, Liu, Haizhen, Wan, Stephanie Winn Chee, Li, Qingyun, Zeng, Chuyue, Law, Carmen Oi Kwan, Chan, Gordon Ho Ching, Lau, Terrence Chi Kong, Ngo, Jacky Chi Ki
Publicado no J Biol Chem (2019)

The ribosomal maturation factor P from Mycobacterium smegmatis facilitates the ribosomal biogenesis by binding to the small ribosomal protein S12

Por Chu, Tinyi, Weng, Xing, Law, Carmen Oi Kwan, Kong, Hoi-Kuan, Lau, Jeffrey, Li, Sheila, Pham, Hoa Quynh, Wang, Rui, Zhang, Liang, Kao, Richard Y. T., Lau, Kwok-Fai, Ngo, Jacky Chi Ki, Lau, Terrence Chi Kong
Publicado no J Biol Chem (2019)

AQAMAN, a bisamidine-based inhibitor of toxic protein inclusions in neurons, ameliorates cytotoxicity in polyglutamine disease models

Por Hong, Huiling, Koon, Alex Chun, Chen, Zhefan Stephen, Wei, Yuming, An, Ying, Li, Wen, Lau, Matthew Ho Yan, Lau, Kwok-Fai, Ngo, Jacky Chi Ki, Wong, Chun-Ho, Au-Yeung, Ho Yu, Zimmerman, Steven C., Chan, Ho Yin Edwin
Publicado no J Biol Chem (2019)