Phosphorylation of FE65 Ser(610) by serum- and glucocorticoid-induced kinase 1 modulates Alzheimer's disease amyloid precursor protein processing

Alzheimer's disease (AD) is a fatal neurodegenerative disease affecting 36 million people worldwide. Genetic and biochemical research indicate that the excessive generation of amyloid-β peptide (Aβ) from amyloid precursor protein (APP), is a major part of AD pathogenesis. FE65 is a brain-enrich...

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Enregistré dans:
Détails bibliographiques
Publié dans:Biochem J
Auteurs principaux: Chow, Wan Ning Vanessa, Ngo, Jacky Chi Ki, Li, Wen, Chen, Yu Wai, Tam, Ka Ming Vincent, Chan, Ho Yin Edwin, Miller, Christopher C.J., Lau, Kwok-Fai
Format: Artigo
Langue:Inglês
Publié: Portland Press Ltd. 2015
Sujets:
Research Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4613528/
https://ncbi.nlm.nih.gov/pubmed/26188042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20141485
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