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Phosphorylation of FE65 at threonine 579 by GSK3β stimulates amyloid precursor protein processing
Excessive generation of amyloid-β peptide (Aβ) by aberrant proteolysis of amyloid precursor protein (APP) is a key event in Alzheimer's disease (AD) pathogenesis. FE65 is a brain-enriched phospho-adaptor protein that interacts with APP and has been shown to modulate APP processing. However, the...
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| I publikationen: | Sci Rep |
|---|---|
| Huvudupphovsmän: | , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
Nature Publishing Group UK
2017
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5622059/ https://ncbi.nlm.nih.gov/pubmed/28963516 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-12334-2 |
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